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Glossary Term

Regional Interdependence

Regional interdependence is the concept that a patient’s primary musculoskeletal symptom(s) may be directly or indirectly related or influenced by impairments from various body regions and systems regardless of proximity to the primary symptom(s). For example, thoracic manipulation having a positive effect on a patient's complaints associated with shoulder impingement syndrome is an example of regional interdependence.

Regional Interdependence: The concept that a patient’s primary musculoskeletal symptom(s) may be directly or indirectly related or influenced by impairments from various body regions and systems regardless of proximity to the primary symptom(s). The clinical implication of this premise is that interventions directed at one region of the body will often have effects in remote and seemingly unrelated areas (1). For example, thoracic manipulation having a positive effect on a patient's complaints associated with shoulder impingement syndrome is an example of regional interdependence. Original Concept introduced by Wainner et al (2).

  1. Sueki, D. G., Cleland, J. A., & Wainner, R. S. (2013). A regional interdependence model of musculoskeletal dysfunction: research, mechanisms, and clinical implications. Journal of Manual & Manipulative Therapy, 21(2), 90-102.
  2. Wainner RS, Flynn TW, Whitman JM. Spinal and extremity manipulation: the basic skill set for physical therapists. San Antonio (TX): Manipulations, Inc; 2001

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